Hey muni5310! All those videos Paul posted are fantastic for understanding Ford electronic returnless systems.
So I could get an idea of which wire the blue/orange wire is, I went to the wiring diagram:
That's it in the lower right. This circuit is part of the command/monitor circuit the PCM and Fuel Pump Driver Module use to communicate back and forth. One wire will be the PCM's commanded fuel pump duty cycle, and the other will be the FPDM's status signal back to the PCM.
Without scoping both wires, it's tough to say which one is which. Because you noted the voltage change during cranking, I'm gonna say that it's normal, and reflecting the PCM's command to the FPDM to run the pump. For more info and scope captures off this FPDM system, check out this other thread on an intermittently starting Econoline

:
scannerdanner.com/forum/post-your-repair...4ford-e450.html#8554
Do you have access to a scope or scan tool? I can recommend some quick pump tests, depending on what you have available.
If this were me, I'd be watching the pump power and ground at the FPDM (white/red and black/pink) during the no start. White red should have power with the key on, and black/pink should be a pulsed ground when the pump is commanded on.